Price A W, Fowler S C
Brain Res. 1981 Jan 26;205(1):81-90. doi: 10.1016/0006-8993(81)90721-6.
Two force transducers which were interfaced with a minicomputer were used as operant manipulanda to assess changes in peak force and rate of response produced by unilateral motor cortical lesions in rats. Spatial arrangement of the manipulanda permitted a subject to respond on Transducer I exclusively with his left forepaw and on Transducer II exclusively with his right. Permanent deficits as measured by both force and rate of response were observed for the limb contralateral to the lesion. In the forelimb ipsilateral to the lesion rate of response was severely depressed immediately following the lesion and, although there was marked recovery during the 10-12 days following surgery, post-lesion rates never attained pre-lesion levels.
两个与小型计算机相连的力传感器被用作操作性操纵装置，以评估大鼠单侧运动皮层损伤后产生的峰值力和反应速率的变化。操纵装置的空间布局允许实验对象仅用左前爪对传感器I做出反应，仅用右前爪对传感器II做出反应。观察到损伤对侧肢体在力量和反应速率方面均出现永久性缺陷。在损伤同侧的前肢，损伤后反应速率立即严重降低，尽管在手术后的10 - 12天内有明显恢复，但损伤后的反应速率从未达到损伤前的水平。
