Wells C, Bøg-Hansen T C, Cooper E H, Glass M R
Clin Chim Acta. 1981 Jan 8;109(1):59-67. doi: 10.1016/0009-8981(81)90137-6.
alpha 1-Acid glycoprotein produces three peaks on crossed immuno-affinoelectrophoresis with concanavalin A in the first dimension, which is indicative of a degree of heterogeneity in the carbohydrate portion of this plasma glycoprotein. A different pattern, however, showing relatively less concanavalin A-binding material, is found in association with and after an increase in female sex hormone levels. Our observations strongly suggest a prolonged hormonal effect on the carbohydrate composition of alpha 1-acid glycoprotein, which may alter the metabolism or the function of the protein.
α1-酸性糖蛋白在一维免疫亲和电泳中与伴刀豆球蛋白A产生三个峰，这表明该血浆糖蛋白碳水化合物部分存在一定程度的异质性。然而，在女性性激素水平升高期间及之后，会出现一种不同的模式，即与伴刀豆球蛋白A结合的物质相对较少。我们的观察结果有力地表明，激素对α1-酸性糖蛋白碳水化合物组成有长期影响，这可能会改变该蛋白的代谢或功能。
