Kleinknecht D, Kourilsky O, Morel-Maroger L, Adhemar J P, Droz D, Masselot J P, Adam C
Clin Nephrol. 1980 Dec;14(6):309-12.
A girl aged 17 developed a nephrotic syndrome with renal insufficiency after narcotic abuse. Renal biopsy showed a diffuse glomerulonephritis with crescents and dense deposits within the glomerular basement membrane; glomerular C3 deposits were present without immunoglobulin. The serum complement profile was typical of activation via the alternative pathway, and tests for C3 nephritic factor were strongly positive. Terminal renal failure occurred within 6 months and required chronic hemodialysis. It is likely that the narcotics used or their contaminants were responsible for the renal damage, presumably by activating the complement system via the alternative pathway.
一名17岁女孩在滥用麻醉品后出现肾病综合征并伴有肾功能不全。肾活检显示为弥漫性肾小球肾炎，伴有新月体形成以及肾小球基底膜内的致密沉积物；肾小球有C3沉积，但无免疫球蛋白。血清补体谱表现为通过替代途径激活的典型特征，C3肾炎因子检测呈强阳性。6个月内出现终末期肾衰竭，需要进行慢性血液透析。很可能是所使用的麻醉品或其污染物导致了肾脏损伤，推测是通过替代途径激活补体系统所致。
