Michalowicz B S, Pihlstrom B L, Drisko C L, Cobb C M, Killoy W J, Caton J G, Lowenguth R A, Quinones C, Encarnacion M, Knowles M
University of Minnesota, Clinical Dental Research Center, Minneapolis, USA.
J Periodontol. 1995 Aug;66(8):708-15. doi: 10.1902/jop.1995.66.8.708.
The purpose of this investigation was to examine periodontal disease recurrence from 3 to 12 months following various treatments with scaling and root planing and controlled-release tetracycline fibers. One-hundred-twenty-two (122) adult volunteers with at least one bleeding pocket > or = 5 mm in each of four quadrants were enrolled in this study. One or two such sites in each quadrant were selected as test sites. Quadrants were randomly assigned to receive one of four treatments: scaling and root planing (S); scaling and root planing plus tetracycline fiber for 10 days (SF); fiber therapy alone for 10 days (F); or fiber therapy alone for 20 days (FF). After treatment, no supportive care was provided during the 12-month study period. Probing depth (PD), attachment loss (AL), plaque, and bleeding on probing were measured at baseline, and at 1, 3, 6, 9, and 12 months after treatment. PD and AL measures were taken at three locations within each site and averaged for each site. Disease recurrence was defined as > or = 1 mm mean attachment loss at a site during the 3- to 12-month period. One-hundred-sixteen (116) subjects completed the study. Sites treated with SF experienced significantly (P < 0.05) less disease recurrence (4%) than S, F, or FF (9%, 10%, and 12%, respectively). Results of this study suggest that, compared to S, F, or FF, scaling and root planing in conjunction with tetracycline fiber therapy for 10 days can significantly reduce disease recurrence 3 to 12 months following treatment in the absence of supportive care.
本研究的目的是在进行了不同的龈下刮治术和根面平整术以及缓释四环素纤维治疗后，对3至12个月内牙周病的复发情况进行检测。122名成年志愿者参与了本研究，他们在四个象限中每个象限至少有一个探诊出血袋≥5mm。每个象限中选取一到两个这样的部位作为测试部位。将象限随机分配接受以下四种治疗之一：龈下刮治术和根面平整术（S）；龈下刮治术和根面平整术加四环素纤维治疗10天（SF）；单独纤维治疗10天（F）；或单独纤维治疗20天（FF）。治疗后，在12个月的研究期间未提供支持性护理。在基线时以及治疗后1、3、6、9和12个月测量探诊深度（PD）、附着丧失（AL）、菌斑和探诊出血情况。在每个部位的三个位置测量PD和AL，并计算每个部位的平均值。疾病复发定义为在3至12个月期间某一部位平均附着丧失≥1mm。116名受试者完成了研究。接受SF治疗的部位疾病复发率（4%）显著低于接受S、F或FF治疗的部位（分别为9%、10%和12%，P<0.05）。本研究结果表明，与S、F或FF相比，龈下刮治术和根面平整术联合四环素纤维治疗10天，在没有支持性护理的情况下，可显著降低治疗后3至12个月的疾病复发率。
