Wilson T G, McGuire M K, Greenstein G, Nunn M
Department of Biostatistics and Dental Public Health Sciences, University of Washington, Seattle, USA.
J Periodontol. 1997 Nov;68(11):1029-32. doi: 10.1902/jop.1997.68.11.1029.
This paper presents 5-year data pertaining to a subgroup of patients from a previous investigation who were treated with scaling and root planing plus tetracycline fibers. The parent study demonstrated that 6 months after therapy, scaling and root planing plus tetracycline fiber therapy was significantly better at reducing probing depth and gaining clinical attachment than scaling and root planing alone. However, the long-term data presented here show a regression from the original gains in clinical attachment levels in the fiber group. Ultimately, the use of fibers provided no significant advantage with regards to probing depth reduction or clinical attachment gain. Within the power of this study, which would have required 1.78 mm of change in clinical attachment to show a difference, there was no significant difference between the treatments at 5 years. This study underscores the need for additional long-term evaluation of this mode of therapy.
本文呈现了来自先前一项研究的部分患者的5年数据，这些患者接受了龈下刮治术和根面平整术加四环素纤维治疗。母研究表明，治疗6个月后，龈下刮治术和根面平整术加四环素纤维治疗在减少探诊深度和获得临床附着方面明显优于单纯的龈下刮治术和根面平整术。然而，此处呈现的长期数据显示，纤维治疗组的临床附着水平从最初的改善出现了倒退。最终，在减少探诊深度或获得临床附着方面，使用纤维并没有显著优势。在本研究的效能范围内（临床附着需要有1.78毫米的变化才能显示出差异），5年时两种治疗方法之间没有显著差异。本研究强调了对这种治疗方式进行更多长期评估的必要性。
