亨廷顿舞蹈症携带者的神经心理学特征：一项双盲研究。
Neuropsychological characteristics of Huntington's disease carriers: a double blind study.
作者信息
Rosenberg N K, Sørensen S A, Christensen A L
机构信息
Department of Clinical Psychology, University Hospital of Aarhus, Risskov, Denmark.
出版信息
J Med Genet. 1995 Aug;32(8):600-4. doi: 10.1136/jmg.32.8.600.
Abstract
A cohort of 33 people at risk for Huntington's disease (HD), applying for genetic testing, were tested with a battery of neuropsychological tests covering attentional, visuospatial, learning, memory, and planning functions. A psychiatric rating scale, SCL-90R, was also applied, mainly as a control, since cognitive dysfunction could be ascribed to functional disorders as well as neurodegenerative processes. Self-rating did not indicate any psychiatric symptoms in carriers or non-carriers. However, significantly inferior cognitive functioning in the gene carriers was disclosed by the neuropsychological tests. Primarily, attentional, learning, and planning functions were affected. It is concluded that premorbid cognitive decline occurs in HD.
摘要
一组33名有亨廷顿舞蹈症（HD）风险且申请基因检测的人，接受了一系列涵盖注意力、视觉空间、学习、记忆和计划功能的神经心理学测试。还应用了一种精神科评定量表SCL - 90R，主要作为对照，因为认知功能障碍可能归因于功能紊乱以及神经退行性过程。自评未显示携带者或非携带者有任何精神症状。然而，神经心理学测试揭示基因携带者的认知功能明显较差。主要是注意力、学习和计划功能受到影响。结论是HD患者病前会出现认知衰退。
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本文引用的文献
1
Explicit memory in Alzheimer's, Huntington's, and Parkinson's diseases.阿尔茨海默病、亨廷顿病和帕金森病中的外显记忆。
Arch Neurol. 1993 Apr;50(4):374-9. doi: 10.1001/archneur.1993.00540040036010.
2
Unimpaired verbal memory and oculomotor control in asymptomatic adults with the genetic marker for Huntington's disease.患有亨廷顿舞蹈病基因标记的无症状成年人的言语记忆和眼球运动控制未受损害。
Arch Neurol. 1993 Aug;50(8):799-802. doi: 10.1001/archneur.1993.00540080010005.
3
A study of psychiatric morbidity in patients with Huntington's disease, their relatives, and controls. Admissions to psychiatric hospitals in Denmark from 1969 to 1991.一项关于亨廷顿舞蹈症患者及其亲属与对照人群精神疾病发病率的研究。丹麦1969年至1991年精神病院收治情况。
Br J Psychiatry. 1993 Dec;163:790-7. doi: 10.1192/bjp.163.6.790.
4
Trinucleotide repeat elongation in the Huntingtin gene in Huntington disease patients from 71 Danish families.来自71个丹麦家庭的亨廷顿病患者中亨廷顿基因的三核苷酸重复序列延长
Hum Mol Genet. 1993 Sep;2(9):1475-6. doi: 10.1093/hmg/2.9.1475.
5
A clinico-genetic study of psychiatric disorder in Huntington's chorea.亨廷顿舞蹈症精神障碍的临床遗传学研究。
Psychol Med. 1993;Suppl 23:1-46. doi: 10.1017/s0264180100001193.
6
A polymorphic DNA marker genetically linked to Huntington's disease.一种与亨廷顿舞蹈症基因连锁的多态性DNA标记。
Nature. 1983;306(5940):234-8. doi: 10.1038/306234a0.
7
The association of affective disorder with Huntington's disease in a case series and in families.
Psychol Med. 1983 Aug;13(3):537-42. doi: 10.1017/s0033291700047966.
8
Neuropsychological testing of Huntington's patients. Clues to progression.亨廷顿氏病患者的神经心理学测试。病情进展的线索。
J Nerv Ment Dis. 1983 Aug;171(8):492-6. doi: 10.1097/00005053-198308000-00006.
9
Patterns of intellectual deficit in Huntington's disease.亨廷顿舞蹈症的智力缺陷模式
J Clin Neuropsychol. 1982 Jul;4(2):173-83. doi: 10.1080/01688638208401127.
10
SCL-90: an outpatient psychiatric rating scale--preliminary report.症状自评量表90：一种门诊精神病评定量表——初步报告
Psychopharmacol Bull. 1973 Jan;9(1):13-28.
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