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[急性嗜酸性粒细胞性肺炎的缓解与复发]

[Remission and relapse of acute eosinophilic pneumonia].

作者信息

Hoshino J, Takahashi T, Aihara T, Takayanagi N

机构信息

Motojima General Hospital, Ohta, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Aug;33(8):878-82.

PMID:7474570
Abstract

A 46-year-old man presented with progressive dyspnea of acute onset, nonproductive coughing, and a high fever. He had been in his usual good health until symptoms began on the previous day. The chest roentgenogram revealed Kerley A and B lines, perivascular cuffing, hilar haze, and bilateral pleural effusins. Body temperature was 37 degrees C and PaO2 was 42 Torr. All clinical and radiographic signs improved. On the 12th hospital day, dyspnea and diffuse infiltration shadows on the chest roentgenogram suddenly occurred again. Acute eosinophilic pneumonia was strongly suspected because of increasing peripheral eosinophilia, and from the results of histologic examination of a specimen obtained by transbronchial lung biopsy. Without steroid treatment, the patient's condition gradually improved. Most cases of eosinophilic pneumonia have been diagnosed as pulmonary infiltration with eosinophilia (PIE). However, this patient did not have PIE syndrome, but instead was given a diagnosis of acute eosinophilic pneumonia, which was first described in 1990. This case may help establish criteria for the diagnosis and steroid treatment of acute eosinophilic pneumonia.

摘要

一名46岁男性,急性起病,进行性呼吸困难,干咳,高热。直至前一天出现症状前,他一直健康状况良好。胸部X线片显示克氏A线和B线、血管周围套袖征、肺门模糊及双侧胸腔积液。体温37℃,动脉血氧分压(PaO2)为42托。所有临床及影像学表现均有改善。住院第12天,患者再次突然出现呼吸困难,胸部X线片出现弥漫性浸润阴影。由于外周血嗜酸性粒细胞增多以及经支气管肺活检标本的组织学检查结果,强烈怀疑为急性嗜酸性粒细胞性肺炎。未经类固醇治疗,患者病情逐渐好转。大多数嗜酸性粒细胞性肺炎病例被诊断为嗜酸性粒细胞增多性肺浸润(PIE)。然而,该患者并无PIE综合征,而是被诊断为急性嗜酸性粒细胞性肺炎,该病于1990年首次被描述。该病例可能有助于确立急性嗜酸性粒细胞性肺炎的诊断及类固醇治疗标准。

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