Matthias M
Arch Geschwulstforsch. 1978;48(5):445-82.
A comprehensive review of the state of development and clinical evaluation of cytostatic agents is given. Special attention is directed to agents which are known for long a time but whose clinical importance has grown only in recent years. This review takes into consideration the chemical structure, mode of action, pharmacokinetics, dosage, side effects, and results of clinical treatment of the following drugs: adriamycin, nitrosourea preparations, DTIC, dibromdulcitol. trofosfamid and ifosfamid, ftorafur, 5-azacytidin, platinum complexes, ICRF-159, cytembena, HMM, VM 26 and VP 16-213, cytostasan, estramustinphosphat, antibody-cytostatic complexes.
本文对细胞抑制剂的发展状况和临床评价进行了全面综述。特别关注那些早已为人所知但其临床重要性直到近年来才有所增加的药物。本综述考虑了以下药物的化学结构、作用方式、药代动力学、剂量、副作用及临床治疗结果：阿霉素、亚硝基脲制剂、氮烯咪胺、二溴卫矛醇、三甲磷酸酯和异环磷酰胺、替加氟、5-氮杂胞苷、铂配合物、ICRF-159、塞替派、六甲蜜胺、VM 26和VP 16-213、细胞生长抑制剂、磷酸雌莫司汀、抗体-细胞抑制复合物。
