抗体亲和力对抗肾小球基底膜肾炎肾损伤诱导的影响。
Effect of antibody avidity on the induction of renal injury in anti-glomerular basement membrane nephritis.
作者信息
Shimizu F, Mossmann H, Takamiya H, Vogt A
出版信息
Br J Exp Pathol. 1978 Dec;59(6):624-9.
Abstract
Antibodies to glomerular basement membrane (GBM) of the rat could be fractionated according to their avidity by elution from trypsin-digested GBM (bound to Sepharose) with increasing concentrations of KSCN. The percentage of kidney-fixing antibody in each fraction and the degree of proteinuria induced as determined 24 h after injection increased with the avidity of the antibody fraction when equal doses were administered.
摘要
大鼠肾小球基底膜（GBM）抗体可通过用浓度递增的硫氰酸钾从胰蛋白酶消化的GBM（结合到琼脂糖珠上）上洗脱，根据其亲和力进行分级分离。当给予等量剂量时，各分级分离物中肾脏固定抗体的百分比以及注射后24小时测定的蛋白尿程度随抗体分级分离物的亲和力增加而增加。
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本文引用的文献
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Localization of the nephrotoxic antigen within the isolated renal glomerulus.肾毒性抗原在分离出的肾肾小球内的定位。
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EXPERIMENTAL GLOMERULONEPHRITIS. V. STUDIES ON THE INTERACTION OF NEPHROTOXIC ANTIBODIES WITH TISSUE OF THE RAT.实验性肾小球肾炎。V. 肾毒性抗体与大鼠组织相互作用的研究
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VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE.免疫应答过程中抗体亲和力的变化
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Studies on the renal glomerular basement membrane. Preparation and chemical composition.肾小球基底膜的研究。制备及化学成分。
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Relationship between affinity of anti-dinitrophenyl antibodies and their biologic activities.抗二硝基苯基抗体的亲和力与其生物学活性之间的关系。
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Effect of variation in antibody-hapten association constant upon the biologic activity of the antibody.抗体-半抗原结合常数的变化对抗体生物活性的影响。
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The immunopathological significance of the heterogeneity of antibody affinity.抗体亲和力异质性的免疫病理学意义。
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The glomerular mesangium. I. Kinetic studies of macromolecular uptake in normal and nephrotic rats.肾小球系膜。I. 正常和肾病大鼠中大分子摄取的动力学研究。
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A method of trace iodination of proteins for immunologic studies.一种用于免疫学研究的蛋白质微量碘化方法。
Int Arch Allergy Appl Immunol. 1966;29(2):185-9. doi: 10.1159/000229699.
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