Heath S L, Tew J G, Tew J G, Szakal A K, Burton G F
Department of Microbiology & Immunology, Virginia Commonwealth University, Richmond 23298-0678, USA.
Nature. 1995 Oct 26;377(6551):740-4. doi: 10.1038/377740a0.
Large amounts of human immunodeficiency virus (HIV) localize on follicular dendritic cells (FDC) in the follicles of secondary lymphoid tissues following viral infection. During clinical latency, active viral infection occurs primarily at these sites. As HIV on FDC is in the form of immune complexes, some of which may be formed with neutralizing antibody, we investigated whether HIV on FDC is infectious. We report here that HIV on FDC is highly infectious. Furthermore, FDC can convert neutralized HIV into an infectious form even in the presence of a vast excess of neutralizing antibody. Thus FDC may provide a mechanism whereby HIV infection can continue in the presence of neutralizing antibody.
病毒感染后，大量人类免疫缺陷病毒（HIV）定位于次级淋巴组织滤泡中的滤泡树突状细胞（FDC）上。在临床潜伏期，活跃的病毒感染主要发生在这些部位。由于FDC上的HIV呈免疫复合物形式，其中一些可能是与中和抗体形成的，因此我们研究了FDC上的HIV是否具有传染性。我们在此报告，FDC上的HIV具有高度传染性。此外，即使存在大量过量的中和抗体，FDC也能将被中和的HIV转化为具有传染性的形式。因此，FDC可能提供了一种机制，使得在存在中和抗体的情况下HIV感染仍能继续。
