Akdemir H, Selçuklu A, Paşaoğlu A, Oktem I S, Kavuncu I
Department of Neurosurgery, Erciyes University, School of Medicine, Kayseri, Turkey.
Neurosurg Rev. 1995;18(2):95-100. doi: 10.1007/BF00417665.
During the last three years, seven patients with severe intraventricular hemorrhage admitted to our clinic were treated with direct intraventricular infusion of urokinase. In each case, hemorrhage extended into the entire ventricular cavity and cast formation as well as an expansion of third and fourth ventricles were found. On the average, both the third and fourth ventricles became clear on the third day and the lateral ventricle on the ninth day after hemorrhage. Five of the seven patients showed good recovery or only moderate disability, and two died. Infection, convulsion, rebleeding, and peripheral or secondary hemorrhage due to the side effects of urokinase was not encountered during therapy. We conclude that this procedure can be applied effectively and safely in severe intraventricular hemorrhage.
在过去三年中，我院收治的7例严重脑室内出血患者接受了脑室内直接注入尿激酶的治疗。每例患者的出血均蔓延至整个脑室腔，发现有铸型形成以及第三和第四脑室扩张。平均而言，出血后第三天第三和第四脑室变清晰，第九天侧脑室变清晰。7例患者中有5例恢复良好或仅有中度残疾，2例死亡。治疗期间未出现因尿激酶副作用导致的感染、惊厥、再出血以及外周或继发性出血。我们得出结论，该方法可有效且安全地应用于严重脑室内出血。
