Homnick D N, White F, de Castro C
Department of Pediatrics, Michigan State University, Kalamazoo Center for Medical Studies, USA.
Pediatr Pulmonol. 1995 Jul;20(1):50-5. doi: 10.1002/ppul.1950200110.
Impaired mucociliary clearance due to defective ion and water transport and the effects of chronic airway infections lead to stasis of secretions and progressive pulmonary damage in patients with cystic fibrosis (CF). Methods to improve removal of tenacious lung secretions in CF patients contribute to slowing the decline in respiratory function. We have evaluated an intrapulmonary percussive ventilator (IPV), which is a device designed to enhance airway clearance and preserve lung function. A previous pilot study by us had determined that the device was acceptable to patients and is safe. We undertook a 6 month parallel comparative trial of the IPV versus standard, manual chest physiotherapy in 16 CF children and adults. No significant differences in spirometric measures, numbers of hospitalizations, use of oral or IV antibiotics, or anthropometric measurements were detected between the standard aerosol/chest physiotherapy group and the IPV group over the duration of the trial. Patient acceptance, as determined by participant survey, was good. The device appeared to be safe and durable. It was concluded that the IPV is as effective as standard aerosol and chest physiotherapy in preserving lung function and anthropometric measures, and there was no difference in the use of antibiotics and hospitalizations.
由于离子和水转运缺陷导致的黏液纤毛清除功能受损以及慢性气道感染的影响，会致使囊性纤维化（CF）患者出现分泌物淤滞和进行性肺损伤。改善CF患者黏稠肺分泌物清除的方法有助于减缓呼吸功能的下降。我们评估了一种肺内叩击通气机（IPV），这是一种旨在增强气道清除和保护肺功能的设备。我们之前的一项初步研究已确定该设备为患者所接受且安全。我们对16名CF儿童和成人进行了一项为期6个月的IPV与标准手动胸部物理治疗的平行对照试验。在试验期间，标准雾化/胸部物理治疗组和IPV组在肺功能测定指标、住院次数、口服或静脉使用抗生素情况或人体测量指标方面均未检测到显著差异。通过参与者调查确定，患者的接受度良好。该设备似乎安全且耐用。得出的结论是，在保护肺功能和人体测量指标方面，IPV与标准雾化和胸部物理治疗同样有效，并且在抗生素使用和住院情况方面没有差异。
