Carneiro F, Seixas M, Sobrinho-Simões M
Institute of Molecular Pathology and Immunology, University of Porto (IPATIMUP), Medical Faculty of Porto, Portugal.
Pathol Res Pract. 1995 Jul;191(6):571-84. doi: 10.1016/S0344-0338(11)80878-2.
Based upon the results of a thorough study of 213 patients submitted to potentially curative resection we propose the following histologic classification of gastric carcinoma: isolated-cell carcinoma (6.6%), glandular carcinoma (41.8%), solid carcinoma (13.1%) and mixed carcinoma (38.5%). Half of the mixed carcinomas displayed a predominant isolated-cell pattern, whereas in the other half the isolated-cells were a minor component (the predominant component being either glandular, solid, or both). The survival of patients with mixed carcinomas is significantly worse than those of patients with other histologic types of gastric carcinoma regardless of the site of tumors and the inclusion, or not, in the series, of post-operative deaths. The proposed classification keeps its independent prognostic significance in a multifactorial analysis, appearing as the second most important prognostic factor in patients with gastric carcinomas, after the TNM staging and before venous invasion.
基于对213例行潜在根治性切除术患者的全面研究结果，我们提出以下胃癌组织学分类：孤立细胞癌（6.6%）、腺癌（41.8%）、实体癌（13.1%）和混合癌（38.5%）。一半的混合癌表现为以孤立细胞为主的模式，而另一半中孤立细胞则是次要成分（主要成分是腺性、实性或两者皆有）。无论肿瘤部位如何，也无论系列研究中是否纳入术后死亡病例，混合癌患者的生存率均显著低于其他组织学类型的胃癌患者。在多因素分析中，所提出的分类具有独立的预后意义，是胃癌患者中第二重要的预后因素，仅次于TNM分期，排在静脉侵犯之前。
