Gálvez J, Sánchez de Medina F, Jiménez J, Torres M I, Fernández M I, Núñez M C, Ríos A, Gil A, Zarzuelo A
Departamento de Farmacología, Facultad de Farmacia, Universidad de Granada, Spain.
Planta Med. 1995 Aug;61(4):302-6. doi: 10.1055/s-2006-958088.
Quercitrin (3-rhamnosylquercetin) is a bioflavonoid contained in several crude drugs traditionally used for its antidiarrhoeal activity. The antidiarrhoeic effect of quercitrin on experimental chronic diarrhoea in rats was studied. Adult rats were fed for 14 days with a synthetic diet in which all soluble carbohydrates were substituted by lactose, resulting in chronic diarrhoea with body weight loss, colonic hyperplasia, reduced average cell size, increased alkaline phosphatase activity, increased mucus production and cytopathological alterations of the enterocyte. The rest of the animals were allowed to recover from chronic diarrhoea for 3 or 7 days, by feeding them with a standard diet, and half of them were also given quercitrin orally (50 mg/kg day). Diarrhoea ceased 48 h after lactose withdrawal, and body weight recovery was apparent after 3 days. Nevertheless, most of the alterations of the colonic mucosa persisted at that time. Quercitrin-treated rats had less diarrhoeal output and did not show mucosal hyperplasia after three days of treatment. All animals had greatly recovered by the seventh day, but histological alterations were still present, although to a lesser extent in quercitrin-treated rats. Quercitrin and related flavonoids may play a role in intestinal repair following chronic mucosal injury.
槲皮苷（3-鼠李糖基槲皮素）是一种生物类黄酮，存在于几种传统上因其止泻活性而使用的生药中。研究了槲皮苷对大鼠实验性慢性腹泻的止泻作用。成年大鼠用一种合成饮食喂养14天，其中所有可溶性碳水化合物都被乳糖替代，导致慢性腹泻，并伴有体重减轻、结肠增生、平均细胞大小减小、碱性磷酸酶活性增加、黏液分泌增加以及肠上皮细胞的细胞病理学改变。其余动物通过喂食标准饮食从慢性腹泻中恢复3天或7天，其中一半还口服给予槲皮苷（50毫克/千克/天）。停止给予乳糖48小时后腹泻停止，3天后体重明显恢复。然而，此时结肠黏膜的大多数改变仍然存在。经槲皮苷治疗的大鼠腹泻量较少，治疗三天后未出现黏膜增生。到第七天所有动物都已大为恢复，但组织学改变仍然存在，不过在经槲皮苷治疗的大鼠中程度较轻。槲皮苷及相关类黄酮可能在慢性黏膜损伤后的肠道修复中发挥作用。
