Basnet P, Kadota S, Shimizu M, Takata Y, Kobayashi M, Namba T
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.
Planta Med. 1995 Oct;61(5):402-5. doi: 10.1055/s-2006-958124.
Bellidifolin, isolated from Swertia japonica, was found to be a potent hypoglycemic agent in STZ-induced diabetic rats by both oral and intraperitoneal administration. Bellidifolin significantly lowered the loaded glucose level in normal as well as diabetic rats. Bellidifolin also lowered blood triglyceride levels significantly. It stimulated glucose uptake activity in Rat 1 fibroblasts expressing human insulin receptors.
从日本獐牙菜中分离出的雏菊叶龙胆素，经口服和腹腔注射给药后，在链脲佐菌素诱导的糖尿病大鼠中被发现是一种有效的降血糖剂。雏菊叶龙胆素能显著降低正常大鼠和糖尿病大鼠的负荷血糖水平。它还能显著降低血液甘油三酯水平。它刺激表达人胰岛素受体的大鼠1成纤维细胞的葡萄糖摄取活性。
