Callard G V, Petro Z, Ryan K J
Endocrinology. 1978 Dec;103(6):2283-90. doi: 10.1210/endo-103-6-2283.
Metabolism of [3H]androstenedione was studied in brain tissue homogenates of opossum, bird, snake, sea turtle, urodele amphibian, teleost, shark, skate, hagfish, and lobster. Estrone, 17 beta-estradiol, or 17 alpha-estradiol was formed by central neural tissues of all species, with the exception of the opossum, hagfish, and lobster. Aromatase activity was concentrated in the forebrain, although some estrogen was synthesized by mid- or hindbrain homogenates of two lower vertebrates (teleost and skate) and the newly hatched chick. 5 alpha-Androstanedione (5 alpha-androstane-3,17-dione) or 5 alpha-dihydrotestosterone were products of metabolism in several nonmammalian vertebrates and in the invertebrate central nervous system also. 5 alpha-Reductase was found in all major brain divisions. These and previously reported comparative studies indicate that the ability to aromatize and otherwise transform androgen substrates is a primitive characteristic of the brain that has been widely conserved phylogenetically.
在负鼠、鸟类、蛇、海龟、有尾两栖动物、硬骨鱼、鲨鱼、鳐鱼、盲鳗和龙虾的脑组织匀浆中研究了[3H]雄烯二酮的代谢。除负鼠、盲鳗和龙虾外，所有物种的中枢神经组织均能生成雌酮、17β-雌二醇或17α-雌二醇。芳香化酶活性集中在前脑，不过两种低等脊椎动物（硬骨鱼和鳐鱼）以及新孵化出的雏鸡的中脑或后脑匀浆也能合成一些雌激素。5α-雄烷二酮（5α-雄甾烷-3,17-二酮）或5α-双氢睾酮也是几种非哺乳类脊椎动物以及无脊椎动物中枢神经系统代谢的产物。在所有主要脑区均发现了5α-还原酶。这些以及之前报道的比较研究表明，雄激素底物的芳香化及其他转化能力是大脑的一种原始特征，在系统发育过程中得到了广泛保留。
