Chinn R J, Wilkinson I D, Hall-Craggs M A, Paley M N, Miller R F, Kendall B E, Newman S P, Harrison M J
Department of Radiology, Middlesex Hospital, University College London Hospitals Trust, England.
Radiology. 1995 Dec;197(3):649-54. doi: 10.1148/radiology.197.3.7480733.
To differentiate intracranial lymphoma from Toxoplasma gondii lesions in patients infected with the human immunodeficiency virus, by means of localized spin-echo proton magnetic resonance (MR) spectroscopy.
Twenty-seven lesions were studied (18 T gondii lesions, nine lymphoma lesions) at 1.5 T. Spectra were acquired at an echo time of 135 msec from voxels centered on the lesions. Both visual analysis and spectral fitting were used to obtain metabolite ratios for choline (Cho), creatine (Cr), N-acetyl (NA), lactate, and lipids.
Three spectral categories were seen. One had large lipid peaks with suppression of other metabolites. Another had an elevated Cho/Cr ratio with relatively diminished NA. The third had features of the other two. Examples of each spectrum type were acquired from both T gondii and lymphoma lesions. Neither method of analysis allowed differentiation between lesion types. MR spectroscopy showed an overlap of spectra.
The authors conclude that toxoplasmosis and lymphoma cannot be differentiated with spin-echo proton MR spectroscopy at 135 msec.
通过局部自旋回波质子磁共振（MR）波谱分析，鉴别感染人类免疫缺陷病毒患者的颅内淋巴瘤与弓形虫病变。
在1.5T磁场下对27个病变进行研究（18个弓形虫病变，9个淋巴瘤病变）。从以病变为中心的体素中，在回波时间为135毫秒时采集波谱。采用视觉分析和波谱拟合两种方法获取胆碱（Cho）、肌酸（Cr）、N-乙酰基（NA）、乳酸和脂质的代谢物比率。
观察到三种波谱类别。一类有大的脂质峰且其他代谢物受抑制。另一类Cho/Cr比率升高且NA相对减少。第三类具有其他两类的特征。每种波谱类型的示例均取自弓形虫病变和淋巴瘤病变。两种分析方法均无法区分病变类型。MR波谱显示波谱存在重叠。
作者得出结论，在135毫秒时，自旋回波质子MR波谱分析无法区分弓形虫病和淋巴瘤。
