Abdul M, Hoosein N M
Department of Genitourinary Medical Oncology, Houston 77030, USA.
Urol Res. 1995;23(3):185-8. doi: 10.1007/BF00389571.
As proteinuria was found to be common in patients with prostate cancer, the possible presence of elevated urinary immunoglobulin (Ig) levels was investigated. First morning urine samples from 30 patients with androgen-dependent (AD) and 43 patients with androgen-independent (AI) prostate cancer were tested. A sensitive, solid-phase radioimmunoassay and polyclonal antibody interacting with IgG, IgA and IgM was used to screen urine samples. Compared with 15 normal, age-matched, healthy subjects, urinary Ig levels were elevated in 10 of 30 (33%) patients with AD prostate cancer and in 24 of 43 (56%) patients with AI prostate cancer. In the latter group, five of seven (71%) patients with prostatic SCC had elevated urinary Igs. Further analysis of ten urine samples containing increased urinary Ig levels, using antibodies specific for each heavy chain (gamma, alpha and mu) as well as each light chain (kappa and lambda), indicated that patients with a high or moderate elevation in Ig levels had polyclonal gammopathy, whereas those with a low increase in urinary Igs had monoclonal gammopathy of the IgG class. These results indicate, for the first time, a high frequency of an abnormal increase in Ig levels in patients with advanced prostatic carcinoma.
由于发现蛋白尿在前列腺癌患者中很常见，因此对尿免疫球蛋白（Ig）水平升高的可能性进行了调查。检测了30例雄激素依赖性（AD）前列腺癌患者和43例雄激素非依赖性（AI）前列腺癌患者的首次晨尿样本。使用一种敏感的固相放射免疫测定法和与IgG、IgA和IgM相互作用的多克隆抗体来筛查尿样。与15名年龄匹配的正常健康受试者相比，30例AD前列腺癌患者中有10例（33%）尿Ig水平升高，43例AI前列腺癌患者中有24例（56%）尿Ig水平升高。在后一组中，7例前列腺鳞状细胞癌患者中有5例（71%）尿Ig升高。使用针对每条重链（γ、α和μ）以及每条轻链（κ和λ）的特异性抗体对10份尿Ig水平升高的尿样进行进一步分析，结果表明，Ig水平高或中度升高的患者患有多克隆丙种球蛋白病，而尿Ig轻度升高的患者患有IgG类单克隆丙种球蛋白病。这些结果首次表明，晚期前列腺癌患者中Ig水平异常升高的频率很高。
