Kyle R A
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
Aust N Z J Med. 1992 Jun;22(3):291-302. doi: 10.1111/j.1445-5994.1992.tb02127.x.
This is a review of the monoclonal gammopathies, including a discussion of cause. The role of T lymphocytes and B lymphocytes is presented. The recognition of a monoclonal protein in the serum and urine is presented in detail. The frequency of benign and malignant monoclonal gammopathies is provided. A long-term follow-up of 241 patients with apparently benign monoclonal gammopathy is examined closely. In this series, multiple myeloma, macroglobulinaemia, amyloidosis, or related disorders developed in 22% of the 241 patients with long-term disease. The median duration from the recognition of the monoclonal protein until the development of serious disease was approximately eight to ten years. The differentiation of benign from malignant monoclonal gammopathies is examined in detail. The point is made that patients must be followed indefinitely because malignancy may develop more than 20 years later. The association of monoclonal gammopathies with other apparently unrelated diseases is discussed.
这是一篇关于单克隆丙种球蛋白病的综述，包括病因探讨。介绍了T淋巴细胞和B淋巴细胞的作用。详细阐述了血清和尿液中单克隆蛋白的识别。给出了良性和恶性单克隆丙种球蛋白病的发生率。对241例明显良性单克隆丙种球蛋白病患者进行了密切的长期随访。在这个队列中，241例患有长期疾病的患者中有22%发生了多发性骨髓瘤、巨球蛋白血症、淀粉样变性或相关疾病。从识别单克隆蛋白到发生严重疾病的中位持续时间约为八至十年。详细探讨了良性与恶性单克隆丙种球蛋白病的鉴别。强调了必须对患者进行无限期随访，因为恶性病变可能在20多年后才出现。还讨论了单克隆丙种球蛋白病与其他明显无关疾病的关联。
