Wu B, Watanabe H, Nakagawa S, Sugimoto K
Department of Urology, Kyoto Prefectural University of Medicine.
Hinyokika Kiyo. 1995 Sep;41(9):665-8.
The effect of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) on the small intestine in rat, in which augmentation cystoplasty was performed, was examined. Seventeen rats were divided into 3 groups: 1) jejunum-transplanted group (5 cases), 2) ileum-transplanted group (6 cases) and 3) control group without operation (6 cases). A part of the small intestine was transplanted to the urinary bladder, then 0.05% BBN was given for 12 weeks. The rats were killed 30 weeks after the beginning of the administration for histopathological evaluation. Bladder tumors in various grades were confirmed in all the cases. In two cases in the jejunum-transplanted group, transitional cell carcinoma was found in the urinary bladder, one of which had an invasion to the adjacent part of the jejunum to the bladder mucosa. These findings suggest that the metabolic products of carcinogens, excreted into urine, had no effect on the transplanted small intestine.
研究了N-丁基-N-(4-羟丁基)亚硝胺（BBN）对行扩大膀胱成形术大鼠小肠的影响。17只大鼠分为3组：1）空肠移植组（5只），2）回肠移植组（6只）和3）未手术对照组（6只）。将部分小肠移植到膀胱，然后给予0.05%BBN，持续12周。给药开始30周后处死大鼠进行组织病理学评估。所有病例均确诊为不同分级的膀胱肿瘤。空肠移植组有2例在膀胱发现移行细胞癌，其中1例侵犯至空肠与膀胱黏膜相邻部位。这些结果表明，排入尿液中的致癌物代谢产物对移植的小肠没有影响。
