染色体异常的风险，重点关注年轻母亲的活产后代。
Risk of chromosomal abnormalities, with emphasis on live-born offspring of young mothers.
作者信息
Little B B, Ramin S M, Cambridge B S, Schneider N R, Cohen D S, Snell L M, Harrod M J, Johnston W L
机构信息
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032, USA.
出版信息
Am J Hum Genet. 1995 Nov;57(5):1178-85.
In a large public urban hospital obstetrics service with > 123,000 deliveries in a 10-year period (1980-89), the frequencies (0.12%) of any type of chromosomal abnormality and of trisomy syndromes were analyzed for maternal age-related risk, by logistic regression. Focusing on very young gravidas, we found that in the study period there were 9,332 births (7.5% of all deliveries) to mothers < or = 16 years old. Estimated risks of chromosomal abnormalities among offspring associated with very young maternal age (9-16 years) were similar to those age-associated risks of mothers 20-29 years old. Risks of chromosomal abnormalities increase with advancing maternal age and are independent of ethnicity.
在一家大型城市公立医院的产科服务中，10年期间（1980 - 1989年）有超过12.3万例分娩，通过逻辑回归分析了任何类型染色体异常和三体综合征的频率（0.12%）与母亲年龄相关风险。针对非常年轻的孕妇，我们发现在研究期间，有9332例婴儿出生（占所有分娩的7.5%），其母亲年龄小于或等于16岁。与非常年轻的母亲年龄（9 - 16岁）相关的后代染色体异常估计风险与20 - 29岁母亲的年龄相关风险相似。染色体异常的风险随着母亲年龄的增长而增加，且与种族无关。
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