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1
Risk of chromosomal abnormalities, with emphasis on live-born offspring of young mothers.染色体异常的风险，重点关注年轻母亲的活产后代。
Am J Hum Genet. 1995 Nov;57(5):1178-85.
2
A multicenter study of fetal chromosomal abnormalities in Chinese women of advanced maternal age.一项针对中国高龄孕产妇胎儿染色体异常的多中心研究。
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Chromosomal defects and outcome in 1015 fetuses with increased nuchal translucency.1015例颈部透明带增厚胎儿的染色体缺陷与结局
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Multivariate logistic regression analysis of risk factors for birth defects: a study from population-based surveillance data.多变量逻辑回归分析出生缺陷的危险因素：基于人群监测数据的研究。
BMC Public Health. 2024 Apr 15;24(1):1037. doi: 10.1186/s12889-024-18420-1.
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Prenatal diagnosis of a trisomy 7/trisomy 13 mosaicism.7号染色体三体/13号染色体三体嵌合体的产前诊断
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3
Down syndrome and precocious menopause.唐氏综合征与早发性绝经。
J Assist Reprod Genet. 2005 Mar;22(3):129-31. doi: 10.1007/s10815-005-4878-6.
4
International variation in reported livebirth prevalence rates of Down syndrome, adjusted for maternal age.经产妇年龄调整后的唐氏综合征报告活产患病率的国际差异。
J Med Genet. 1999 May;36(5):386-93.

本文引用的文献

1
Rates of chromosome abnormalities at different maternal ages.不同孕产妇年龄的染色体异常发生率。
Obstet Gynecol. 1981 Sep;58(3):282-5.
2
Is routine prenatal karyotyping indicated in pregnancies of very young women?非常年轻女性的孕期是否需要进行常规产前核型分析？
J Pediatr. 1973 Apr;82(4):675-7. doi: 10.1016/s0022-3476(73)80595-5.
3
The effect of maternal age on the incidence of Down's syndrome.
Humangenetik. 1972;16(1):141-6. doi: 10.1007/BF00394000.
4
Down's syndrome at young maternal age; cytogenetical and genealogical study of eighty-two families.年轻母亲生育的唐氏综合征；82个家庭的细胞遗传学和系谱学研究
Ann Hum Genet. 1967 Aug;31(1):51-69.
5
[Chromosome anomalies caused by surplus (trisomies) and age of the mother].
Dtsch Med Wochenschr. 1966 Jul 15;91(28):1262-7. doi: 10.1055/s-0028-1111500.
6
Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomy.按母亲年龄划分的染色体数目异常发生率，特别提及三体性。
Hum Genet. 1985;70(1):11-7. doi: 10.1007/BF00389450.
7
Reproductive potential in the older woman.老年女性的生殖潜力。
Fertil Steril. 1986 Dec;46(6):989-1001. doi: 10.1016/s0015-0282(16)49869-9.
8
Genetic disorders in children and young adults: a population study.儿童和青年的遗传疾病：一项人群研究。
Am J Hum Genet. 1988 May;42(5):677-93.
9
Down syndrome, paternal age, maternal age and birth order.唐氏综合征、父亲年龄、母亲年龄及出生顺序。
Ann Hum Genet. 1978 Jan;41(3):289-98. doi: 10.1111/j.1469-1809.1978.tb01896.x.

染色体异常的风险，重点关注年轻母亲的活产后代。

Risk of chromosomal abnormalities, with emphasis on live-born offspring of young mothers.

作者信息

Little B B, Ramin S M, Cambridge B S, Schneider N R, Cohen D S, Snell L M, Harrod M J, Johnston W L

机构信息

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas 75235-9032, USA.

出版信息

Am J Hum Genet. 1995 Nov;57(5):1178-85.

PMID:7485170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1801352/
Abstract

In a large public urban hospital obstetrics service with > 123,000 deliveries in a 10-year period (1980-89), the frequencies (0.12%) of any type of chromosomal abnormality and of trisomy syndromes were analyzed for maternal age-related risk, by logistic regression. Focusing on very young gravidas, we found that in the study period there were 9,332 births (7.5% of all deliveries) to mothers < or = 16 years old. Estimated risks of chromosomal abnormalities among offspring associated with very young maternal age (9-16 years) were similar to those age-associated risks of mothers 20-29 years old. Risks of chromosomal abnormalities increase with advancing maternal age and are independent of ethnicity.

摘要

在一家大型城市公立医院的产科服务中，10年期间（1980 - 1989年）有超过12.3万例分娩，通过逻辑回归分析了任何类型染色体异常和三体综合征的频率（0.12%）与母亲年龄相关风险。针对非常年轻的孕妇，我们发现在研究期间，有9332例婴儿出生（占所有分娩的7.5%），其母亲年龄小于或等于16岁。与非常年轻的母亲年龄（9 - 16岁）相关的后代染色体异常估计风险与20 - 29岁母亲的年龄相关风险相似。染色体异常的风险随着母亲年龄的增长而增加，且与种族无关。