Bartmann Ana Karina, Araújo Francielle M, Iannetta Odilon, Paneto João C C, Martelli Lúcia, Ramos Ester Silveira
Department of Obstetrics and Gynecology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
J Assist Reprod Genet. 2005 Mar;22(3):129-31. doi: 10.1007/s10815-005-4878-6.
To determine whether women who had children with Down syndrome (DS) had precocious menopause.
We selected 104 mothers of children with DS and 121 normal women who had children with no genetic problems. We conducted an interview and compared their mean age at menopause.
We did not detect a statistically significant difference in mean age at menopause. When we stratified into women who had conceived when younger or older than 35 years of age, we found a statistically significant difference only for women who had conceived at the age of 35 years or older. We observed three cases of previous unilateral ovarian surgery in the study group and one case in the control group.
We cannot conclude that mothers of children with DS will have precocious menopause. Nevertheless, our findings do not exclude the theory of reduced ovarian reserve as a primordial factor in the genesis of DS.
确定生育患有唐氏综合征（DS）孩子的女性是否会出现过早绝经。
我们选取了104名生育患有DS孩子的母亲以及121名生育无遗传问题孩子的正常女性。我们进行了访谈并比较了她们的绝经平均年龄。
我们未检测到绝经平均年龄存在统计学上的显著差异。当我们按35岁及以上或35岁以下受孕的女性进行分层时，仅在35岁及以上受孕的女性中发现了统计学上的显著差异。我们在研究组中观察到3例既往单侧卵巢手术病例，在对照组中观察到1例。
我们不能得出生育患有DS孩子的母亲会过早绝经的结论。然而，我们的研究结果并不排除卵巢储备减少理论是DS发病的一个原始因素。
