Berry V, Jennings K, Woodnutt G
SmithKline Beecham Pharmaceuticals, Brockham Park, Betchworth, Surrey, England.
Antimicrob Agents Chemother. 1995 Aug;39(8):1859-61. doi: 10.1128/AAC.39.8.1859.
The growth kinetics of Helicobacter pylori after it has been exposed to amoxicillin have been investigated in conjunction with studies of cell morphology. A potent bactericidal effect was observed at concentrations 10-fold higher than the MIC, but this was accompanied by an increase in the residual numbers of coccoid forms observed. In the presence of 10 micrograms of amoxicillin per ml, these forms could be detected as rapidly as 6 h after exposure to the antibiotic. Although the clinical relevance of coccoid forms remains unknown, such forms should be considered when potential anti-Helicobacter agents are tested in vitro.
幽门螺杆菌暴露于阿莫西林后的生长动力学已结合细胞形态学研究进行了调查。在浓度比最低抑菌浓度（MIC）高10倍时观察到了强大的杀菌作用，但与此同时，观察到的类球形体残留数量有所增加。在每毫升含10微克阿莫西林的情况下，接触抗生素后6小时就能迅速检测到这些类球形体。尽管类球形体的临床相关性尚不清楚，但在体外测试潜在的抗幽门螺杆菌药物时应考虑到这些形态。
