孟加拉国神经病性豆状核变性患者脑脊液和血清中人类嗜T淋巴细胞病毒I型抗体的研究

Study of HTLV-I antibodies in CSF and serum of neurolathyrism patients in Bangladesh.

作者信息

Haque A, Khan J K, Wouters G, Hossain M, Lambein F

机构信息

Department of Neurology, Institute for Postgraduate Medicine and Research, Dhaka, Bangladesh.

出版信息

Ann Soc Belg Med Trop. 1995 Jun;75(2):131-4.

PMID:7487200

Abstract

Neurolathyrism is a form of human spastic paraparesis related to the overconsumption of the legume Lathyrus sativus or grass pea (Khesari in Bangladesh) containing the neurotoxin 3-N-oxalyl-2,3-diaminopropanoic acid (beta-ODAP). The clinical symptoms of neurolathyrism are similar to those of Tropical Spastic Paraparesis. In order to eliminate the proposed causative agent of TSP (HTLV-I) as a potential cause of the symptoms ascribed to neurolathyrism, a total of 444 diagnosed lathyrism patients were screened for HTLV-I antibodies. 50 CSF and 394 serum samples were collected from male (415) and female (29) patients. Only 4 serum samples were found sero-positive for HTLV-I. This agrees with the assumption that overconsumption of beta-ODAP containing Lathyrus seeds, and not HTLV infection, is the causative agent for neurolathyrism.

摘要

骨豆中毒性麻痹是一种人类痉挛性截瘫，与过量食用含有神经毒素3-N-草酰基-2,3-二氨基丙酸（β-ODAP）的豆科植物草豌豆（孟加拉国称Khesari）有关。骨豆中毒性麻痹的临床症状与热带痉挛性截瘫相似。为了排除热带痉挛性截瘫的假定病原体（人类嗜T淋巴细胞病毒I型，HTLV-I）作为骨豆中毒性麻痹症状的潜在病因，对444例确诊的骨豆中毒患者进行了HTLV-I抗体筛查。从男性（415例）和女性（29例）患者中采集了50份脑脊液样本和394份血清样本。仅发现4份血清样本HTLV-I呈血清阳性。这与以下假设相符，即过量食用含有β-ODAP的草豌豆种子而非HTLV感染是骨豆中毒性麻痹的病原体。