Haque A, Hossain M, Lambein F, Bell E A
Institute for Post Graduate Medical Research, Shahbagh, Dhaka, Bangladesh.
Nat Toxins. 1997;5(1):43-6. doi: 10.1002/(SICI)(1997)5:1<43::AID-NT7>3.0.CO;2-M.
In a study of 500 patients suffering from neurolathyrism in Bangladesh it was found that 60 (all male) complained of bone pain and showed skeletal deformities suggestive of osteolathyrism. On X-ray examination a failure of fusion in both vertebral and iliac epiphyses was found in two patients. At the age of these patients (30 and 37 years) such failure was considered a clear evidence of osteolathyrism. All 60 patients were accustomed to eating the green parts of Lathyrus sativus, which contain 2-cyanoethyl-isoxazolin-5-one, a compound that chemically and metabolically can produce the osteolathyrogen beta-aminopropionitrile (BAPN), as well as foods made from the seeds of the same plant which contain the neurotoxin 3-N-oxalyl-2,3-diaminopropanoic acid (beta-ODAP).
在孟加拉国对500名患有骨软化症的患者进行的一项研究中，发现60名患者（均为男性）抱怨骨痛并表现出提示骨软化症的骨骼畸形。经X光检查，两名患者的椎体和髂骨骨骺均未融合。在这些患者的年龄（30岁和37岁），这种未融合被认为是骨软化症的明确证据。所有60名患者都习惯食用含有2-氰基乙基异恶唑啉-5-酮的香豌豆的绿色部分，该化合物在化学和代谢上可产生致骨软化因子β-氨基丙腈（BAPN），以及由同一植物种子制成的含有神经毒素3-N-草酰基-2,3-二氨基丙酸（β-ODAP）的食物。
