Czarny A, Witkowska D, Mulczyk M
Department of Immunology of Infectious Diseases, Polish Academy of Sciences, Wrocław.
Arch Immunol Ther Exp (Warsz). 1994;42(3):159-61.
The kinetics of interleukin (IL-2) release from mouse spleen cells incubated with different doses of outer membrane proteins (OMP) from Shigella was investigated. OMP induced very low activity of IL-2 after 2 and 4 h, and only a slightly higher level of the cytokine was detected after 6 h. However, IL-2 activity increased markedly after 20 and 24 h of incubation, and doses of 5 and 10 micrograms of OMP were found to be the most effective. Spleen cells cultured with OMP for 48 h contained reduced concentration of IL-2.
