Melezyńska-Matej M, Wróbel G, Bogusławska-Jaworska J, Grzybek-Hryncewicz K
Department of Microbiology, Medical Academy, Wrocław, Poland.
Arch Immunol Ther Exp (Warsz). 1994;42(4):337-43.
Twenty seven children with hematological malignancies were treated with Sandoglobulin for life threatening infections due to severe granulocytopenia. We have studied the opsonic activity of sera in patients before and 7,14 and 21 days after the infusion of Sandoglobulin. Before the therapy a decrease of serum opsonic activity at the stage of ingestion and intracellular killing of bacteria has been shown. It was due to a deficiency of opsonizing factors. After treatment with Sandoglobulin the significant improvement of the opsonic activity of tested sera was found, but only at the stage of the ingestion of bacteria. The optimal interrelationship between opsonizing capacity of sera at the ingestion and intracellular killing phase was observed in the group of children treated with the relatively low Sandoglobulin dose (0.3-0.6 g/kg). In patients with the longest infection duration, who received the high Sandoglobulin doses (> 0.6 g/kg), the largest percentage of sera containing immune complexes was detected. These data demonstrate that high doses of globulins should be administered with certain care.
27例血液系统恶性肿瘤患儿因严重粒细胞减少发生危及生命的感染，接受了静脉注射免疫球蛋白（Sandoglobulin）治疗。我们研究了这些患儿在输注Sandoglobulin之前以及输注后7天、14天和21天血清的调理活性。治疗前已显示，在细菌摄取和细胞内杀伤阶段血清调理活性降低，这是由于调理因子缺乏所致。使用Sandoglobulin治疗后，检测到受试血清的调理活性有显著改善，但仅在细菌摄取阶段。在接受相对低剂量Sandoglobulin（0.3 - 0.6 g/kg）治疗的儿童组中，观察到血清在摄取和细胞内杀伤阶段的调理能力之间存在最佳的相互关系。在感染持续时间最长且接受高剂量Sandoglobulin（> 0.6 g/kg）的患者中，检测到含有免疫复合物的血清比例最高。这些数据表明，高剂量球蛋白的使用应谨慎。
