Melezyńska-Matej M, Koziełł J, Tołkacz M, Czernik J, Grzybek-Hryncewicz K
Katedra i Zakład Mikrobiologii Akademii Medycznej we Wrocławiu.
Pediatr Pol. 1996 Jun;71(6):511-6.
The concentration of acute phase proteins following burn is known to increase in serum rapidly, while that of fibronectin often decreases. Fibronectin (Fn) has been demonstrated to serve as an opsonin involved in the ingestion phase in phagocytic process. On the other hand, some acute phase proteins such as alpha-1 acid glycoprotein (AG) may inhibit phagocytic activity. In our study, the phagocytic activity of normal granulocytes was decreased by those sera in which a high level of AG was accompanied by a fall in the Fn Level. Attempts to detect a possible link between the acute phase response and fibronectin led as to study whether fibronectin and AG may interact antagonistically on the phagocytic activity of neutrophils. For this reason we calculated the Fn/Ag coefficient. We showed that an Fn/Ag coefficient in normal sera equals more than 0.20. The higher the coefficient, the better the opsonic activity of sera. We propose here that an Fn/AG coefficient may be a useful risk factor for infections in burned patients.
已知烧伤后急性期蛋白的浓度会在血清中迅速升高，而纤连蛋白的浓度通常会降低。纤连蛋白（Fn）已被证明在吞噬过程的摄取阶段作为一种调理素发挥作用。另一方面，一些急性期蛋白，如α-1酸性糖蛋白（AG），可能会抑制吞噬活性。在我们的研究中，正常粒细胞的吞噬活性会被那些AG水平高且Fn水平下降的血清所降低。为了检测急性期反应与纤连蛋白之间可能存在的联系，我们研究了纤连蛋白和AG是否可能对中性粒细胞的吞噬活性产生拮抗作用。因此，我们计算了Fn/Ag系数。我们发现正常血清中的Fn/Ag系数大于0.20。该系数越高，血清的调理活性越好。我们在此提出，Fn/AG系数可能是烧伤患者感染的一个有用风险因素。
