Qian K X, Wang S S, Chu S H
Department of Surgery, Medical College of Taiwan University, Taipei, Republic of China.
Perfusion. 1995 Jul;10(4):257-63. doi: 10.1177/026765919501000409.
A pulsatile implantable impeller pump was tested as a left ventricular assist device in five calves. The experiments lasted for 4-11 days. Death or termination was mainly due to respiratory complications or bleeding, irrelevant to the pump itself. As indicators of haemolysis, thrombogenesis, renal and hepatic functions, free haemoglobin (FHb), haematocrit (Hct), platelet number (Plt), lactate dehydrogenase (LDH), blood urea nitrogen (BUN), creatinine, serum glutamic oxalacetic transaminase (GOT) and total bilirubin were measured preoperatively, at the beginning of the pumping (pump on), six hours later and every day thereafter. The data indicated that the pump caused no severe blood damage or organ dysfunction. Thus, the feasibility of a pulsatile centrifugal pump was demonstrated. The pump with its driver weighs 110 g and is capable of delivering a blood flow up to 8 l/min against 100 mmHg mean pressure.
一种脉动式植入式叶轮泵作为左心室辅助装置在5只小牛身上进行了测试。实验持续了4至11天。死亡或实验终止主要是由于呼吸并发症或出血，与泵本身无关。作为溶血、血栓形成、肾和肝功能的指标，术前、开始泵血时（泵开启）、6小时后及此后每天测量游离血红蛋白（FHb）、血细胞比容（Hct）、血小板计数（Plt）、乳酸脱氢酶（LDH）、血尿素氮（BUN）、肌酐、血清谷氨酸草酰乙酸转氨酶（GOT）和总胆红素。数据表明该泵未造成严重血液损伤或器官功能障碍。因此，证明了脉动式离心泵的可行性。该泵及其驱动器重110克，能够在平均压力100 mmHg下输送高达8升/分钟的血流。
