Qian K X, Wang S S, Chu S H
Department of Surgery, Medical College of National Taiwan University, Taipei, ROC.
Med Eng Phys. 1996 Jun;18(4):320-5. doi: 10.1016/1350-4533(95)00050-x.
A pulsatile impeller total heart was developed, which consists of two impeller pumps and a d.c. motor. As the motor changes its rotating speed periodically, both pumps eject the blood flow simultaneously. To evaluate its blood compatibility, the device and sarns roller pumps were compared in two series of acute biventricular assist experiments in four and three pigs, respectively. The experimental conditions were controlled to be as equal as possible. The experiments lasted 6 hours. Blood sampling was drawn preoperatively, at the beginning of the pumping and every 2 h postoperatively. Red blood cells (RBC), white blood cells (WBC), platelets (PLT), hematocrit (HCT), hemoglobin (HB), free hemoglobin (FHB) and lactate dehydrogenase (LDH) were measured. The results demonstrated that there was no significant blood damage caused by impeller total heart and the clinically used roller, and that the pulsatile impeller total heart is suitable for chronic animal experiments.
开发了一种搏动式叶轮全人工心脏，它由两个叶轮泵和一台直流电机组成。随着电机周期性地改变其转速，两个泵同时喷射血流。为了评估其血液相容性，分别在四头和三头猪身上进行了两组急性双心室辅助实验，将该装置与萨恩斯滚压泵进行了比较。实验条件被控制得尽可能相等。实验持续了6小时。术前、开始泵血时及术后每2小时采集血样。检测红细胞（RBC）、白细胞（WBC）、血小板（PLT）、血细胞比容（HCT）、血红蛋白（HB）、游离血红蛋白（FHB）和乳酸脱氢酶（LDH）。结果表明，叶轮全人工心脏和临床使用的滚压泵均未造成明显的血液损伤，搏动式叶轮全人工心脏适用于慢性动物实验。
