Theunissen J J, Kariwiga G, Ossewaarde J M, van Rijsoort-Vos J H, Stolz E, van der Meijden W I
Department of Dermato-Venereology, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
Genitourin Med. 1995 Oct;71(5):295-8. doi: 10.1136/sti.71.5.295.
To determine the prevalence of Chlamydia trachomatis infection in women attending a family planning clinic in Papua New Guinea, in the period between April and June 1991.
The outpatient department of Obstetrics and Gynaecology of Port Moresby General Hospital, Port Moresby, Papua New Guinea, the departments of Dermato-Venereology and Clinical Microbiology of the Erasmus University, Rotterdam, The Netherlands and the National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
A total of 254 consecutive women who attended the family planning clinic at Port Moresby General Hospital, Papua New Guinea were enrolled into this study.
Cervical infections with C trachomatis were diagnosed using the direct immunofluorescent assay (DFA) and the polymerase chain reaction (PCR). Serum IgM and IgG antibodies directed against C trachomatis were detected using the enzyme-linked fluorescent assay (ELFA).
The prevalence of C trachomatis was 14.6% using the PCR, 9.1% using the DFA and 17.3% when the results of the PCR and the DFA were combined. An elevated IgM titre was observed in 14.2% of the women, whereas 44.1% had an elevated IgG titre. The titres of IgM or IgG were significantly higher in women who were positive using the PCR or the DFA than in those who were negative in both the PCR and the DFA (p = 0.032 and p = 0.0046, respectively).
Cervical infection by C trachomatis can be considered a major health problem in at least the studied population in Papua New Guinea. The prevalence of C trachomatis infection is at least comparable with that in groups with a high prevalence in industrialized countries. Effective screening and treatment programmes are imperative to combat this problem.
确定1991年4月至6月期间，巴布亚新几内亚一家计划生育诊所就诊女性沙眼衣原体感染的患病率。
巴布亚新几内亚莫尔斯比港莫尔斯比港总医院妇产科门诊部、荷兰鹿特丹伊拉斯姆斯大学皮肤性病学和临床微生物学系以及荷兰比尔瑟姆国家公共卫生和环境保护研究所。
共有254名连续就诊于巴布亚新几内亚莫尔斯比港莫尔斯比港总医院计划生育诊所的女性纳入本研究。
采用直接免疫荧光法（DFA）和聚合酶链反应（PCR）诊断沙眼衣原体宫颈感染。使用酶联荧光法（ELFA）检测针对沙眼衣原体的血清IgM和IgG抗体。
采用PCR检测沙眼衣原体患病率为14.6%，采用DFA检测为9.1%，PCR和DFA结果合并时为17.3%。14.2%的女性IgM滴度升高，而44.1%的女性IgG滴度升高。PCR或DFA检测呈阳性的女性IgM或IgG滴度显著高于PCR和DFA检测均为阴性的女性（p分别为0.032和0.0046）。
沙眼衣原体宫颈感染至少在巴布亚新几内亚的研究人群中可被视为一个主要的健康问题。沙眼衣原体感染的患病率至少与工业化国家高患病率人群相当。必须实施有效的筛查和治疗方案来应对这一问题。
