阿齐霉素A和B，由拟无枝酸菌产生的新型抗菌剂。II. 结构测定。

Azicemicins A and B, new antimicrobial agents produced by Amycolatopsis. II. Structure determination.

作者信息

Tsuchida T, Sawa R, Takahashi Y, Iinuma H, Sawa T, Naganawa H, Takeuchi T

机构信息

Institute of Microbial Chemistry, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1995 Oct;48(10):1148-52. doi: 10.7164/antibiotics.48.1148.

DOI:10.7164/antibiotics.48.1148

PMID:7490223

Abstract

A new structural class of antibiotics, azicemicins A (1) and B (2) were isolated from the culture broth of Amycolatopsis sp. MJ126-NF4. Their structures were elucidated from their physico-chemical properties, various NMR experiments and chemical transformations and were shown to be 3-(1-methyl-2-aziridinyl)- and 3-(2-aziridinyl)-3,4-dihydro-3,7,8,10,12b-pentahydroxy-9,12-dimeth oxy-benz [a]anthracene-1,6(2H,5H)-dione, respectively.

摘要

从拟无枝酸菌属MJ126-NF4的培养液中分离出了一类新型结构的抗生素——氮杂霉素A（1）和B（2）。通过其物理化学性质、各种核磁共振实验以及化学转化确定了它们的结构，结果表明它们分别是3-（1-甲基-2-氮丙啶基）-和3-（2-氮丙啶基）-3,4-二氢-3,7,8,10,12b-五羟基-9,12-二甲氧基-苯并[a]蒽-1,6(2H,5H)-二酮。