二并嘧啶 A 和 B，微生物化合物，从链霉菌属 K16-0194 中分离得到。

Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp. K16-0194.

机构信息

Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.

Team Mirai Group, Fuji Silysia Chemical Ltd., 2-1846 Kozoji-cho, Kasugai, Aichi, 487-0013, Japan.

出版信息

J Antibiot (Tokyo). 2018 May;71(5):535-537. doi: 10.1038/s41429-018-0028-0. Epub 2018 Feb 20.

DOI:10.1038/s41429-018-0028-0

PMID:29463887

Abstract

In a search for compounds interacting with ergosterol resin, a new compound named dipyrimicin B was isolated from a rare actinomycete strain, Amycolatopsis sp. K16-0194. In addition, another analog, dipyrimicin A, which does not interact with the resin, was also discovered. The structures of the two dipyrimicins were established by comprehensive 1D and 2D NMR and MS analyses and found to contain a unique core structure, a 2,2'-bipyridine skeleton. Dipyrimicin A showed strong antimicrobial and cytotoxic activity, whereas dipyrimicin B displayed distinctly poor antimicrobial and cytotoxic activities.

摘要

在寻找与麦角甾醇树脂相互作用的化合物的过程中，从稀有放线菌菌株 Amycolatopsis sp. K16-0194 中分离到一种新的化合物，名为双嘧啶霉素 B。此外，还发现了另一种类似物，双嘧啶霉素 A，它与树脂不相互作用。通过全面的 1D 和 2D NMR 和 MS 分析确定了这两种双嘧啶霉素的结构，它们都含有独特的核心结构，即 2,2'-联吡啶骨架。双嘧啶霉素 A 表现出强烈的抗菌和细胞毒性活性，而双嘧啶霉素 B 则表现出明显较差的抗菌和细胞毒性活性。