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患有胸骨前皮肤黑色素瘤和肩部基底细胞癌患者的下眼睑高危基底细胞癌:唇颊推进皮瓣联合潜行剥离手术方法作为一种有前景的复杂一步治疗选择!

High-Risk BCC Of the Lower Eyelid in Patient with Presternal Located Cutaneous Melanoma and BCC Of the Shoulder: Melolabial Advancement Flap Combined with Undermining Surgical Approach As Promising Complex One Step Treatment Option!

作者信息

Tchernev Georgi, Lozev Ilia, Pidakev Ivan, Yungareva Irina, Naskova-Popova Tanya, Temelkova Ivanka

机构信息

Medical Institute of Ministry of Interior (MVR), Department of Dermatology, Venereology and Dermatologic Surgery, General Skobelev Nr 79, Sofia, Bulgaria.

Onkoderma - Policlinic for Dermatology and Dermatologic Surgery, General Skobelev 26, Sofia, Bulgaria.

出版信息

Open Access Maced J Med Sci. 2018 Nov 21;6(11):2147-2151. doi: 10.3889/oamjms.2018.408. eCollection 2018 Nov 25.

Abstract

BACKGROUND

It is assumed that the occurrence of keratinocyte and melanocytic tumours is multifactorial driven. Certain risk factors such as solar radiation, p53 protein and Melanocortin-1 receptor (MC1R) prove to be common to their development, which at the same time shows that their simultaneous manifestation in the same patients, for example, is quite possible. Such a manifestation could be observed as collision tumours within the same solitary lesion or as a simultaneous occurrence within two completely different lesions that are clearly distinguished from one another.

CASE REPORT

An 85-year-old patient is presented with three primary cutaneous tumours located in region presternal, infraorbital sinistra and scapularis extra. The lesions were removed during a single surgical session. For the high-risk basal cell carcinoma (BCC) in the lower eyelid, the so-called melolabial advancement flap was applied, and for the tumours located in the other two areas, the undermining surgical approach was applied. The subsequent histological analysis found that the case referred to two keratinocyte tumours (BCC) and one melanocyte tumour (cutaneous melanoma).

CONCLUSIONS

The patient presented is interesting with regard to 1) the simultaneous presentation of three primaries with different localization (so far not described in the world literature, namely 2 basal cell carcinomas and one melanoma in the same patient concurrently), 2) one of the basal cell tumours belongs to the group of high-risk (according to the localization) and meanwhile advanced BCC (according to the infiltration degree of the underlying tissue-infiltration of the musculature) and 3) their simultaneous successful surgical treatment in a single surgical session under local anaesthesia.

摘要

背景

据推测,角质形成细胞和黑素细胞肿瘤的发生是由多因素驱动的。某些风险因素,如太阳辐射、p53蛋白和黑素皮质素-1受体(MC1R),被证明是它们发展的共同因素,这同时表明它们在同一患者中同时出现是完全可能的。这种表现可以在同一孤立病变内观察为碰撞肿瘤,或者在两个彼此明显不同的完全不同的病变中同时出现。

病例报告

一名85岁患者出现了三个原发性皮肤肿瘤,分别位于胸骨前区、左眶下和肩胛外区。这些病变在一次手术中被切除。对于下眼睑的高危基底细胞癌(BCC),采用了所谓的鼻唇推进皮瓣,对于位于其他两个区域的肿瘤,采用了潜行剥离手术方法。随后的组织学分析发现,该病例涉及两个角质形成细胞肿瘤(BCC)和一个黑素细胞肿瘤(皮肤黑色素瘤)。

结论

该患者具有以下几点值得关注:1)同时出现三个不同部位的原发性肿瘤(世界文献中尚未描述,即同一患者同时出现2个基底细胞癌和1个黑色素瘤);2)其中一个基底细胞肿瘤属于高危组(根据部位),同时是进展期基底细胞癌(根据其对深层组织——肌肉组织的浸润程度);3)在局部麻醉下,一次手术成功地同时切除了这些肿瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0178/6290402/1689d245ae9e/OAMJMS-6-2147-g001.jpg

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