Nabi H A, Erb D A, Cronin V R
Department of Nuclear Medicine, State University of New York at Buffalo 14214-3007, USA.
Nucl Med Commun. 1995 Aug;16(8):631-9. doi: 10.1097/00006231-199508000-00003.
The aim of this study was to assess the contribution of single photon emission tomography (SPET) to planar imaging of colorectal carcinoma in patients being evaluated with 111In-labelled monoclonal antibodies CYT-103 (OncoScint CR/OV) or IVP ZCE 025. Planar and SPET scans from 110 colorectal carcinoma patients were scored individually as follows: 1=negative, 2=equivocal, 3=positive. The planar and SPET images identified 67 and 93 of 113 documented lesions, respectively. The planar and SPET findings were concordant in 55 patients. SPET converted planar findings from 1 to 3 in 11 patients and from 2 to 3 in 21 patients. SPET provided a better definition of the extent of the tumour in 21 patients. Both imaging tests were true-negative in five patients, and failed to detect tumours in six patients. We strongly recommended SPET in all patients undergoing immunoscintigraphy, since it identified tumours missed on planar scans in 35% of patients and provided additional information regarding tumour burden in 23% of patients.
本研究的目的是评估单光子发射断层扫描（SPET）对使用铟-111标记的单克隆抗体CYT-103（OncoScint CR/OV）或IVP ZCE 025进行评估的结直肠癌患者平面成像的贡献。对110例结直肠癌患者的平面和SPET扫描分别进行如下评分：1=阴性，2=可疑，3=阳性。平面和SPET扫描分别识别出113个已记录病变中的67个和93个。55例患者的平面和SPET结果一致。SPET使11例患者的平面检查结果从1转为3，21例患者从2转为3。SPET为21例患者更清晰地显示了肿瘤范围。两种成像检查在5例患者中均为真阴性，6例患者未检测到肿瘤。我们强烈建议对所有接受免疫闪烁显像的患者进行SPET检查，因为它能发现35%的患者平面扫描遗漏的肿瘤，并为23%的患者提供有关肿瘤负荷的额外信息。
