来自凝乳状睡茄的抗真菌甾体内酯。

Antifungal steroidal lactones from Withania coagulance.

作者信息

Choudhary M I, Parveen Z, Jabbar A, Ali I

机构信息

H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.

出版信息

Phytochemistry. 1995 Nov;40(4):1243-6. doi: 10.1016/0031-9422(95)00429-b.

DOI:10.1016/0031-9422(95)00429-b

PMID:7492372

Abstract

Two new withanolides, 14,15 beta-epoxywithanolide I [(20S,22R) 17 beta, 20 beta-dihydroxy-14 beta,15 beta-epoxy-1-oxo-witha-3,5,24-trienolide] and 17 beta-hydroxywithanolide K (20S,22R) 14 alpha,17 beta,20 beta-trihydroxy-1-oxo-witha-2,5,24-trienolide] have been isolated from the whole plant of Withania coagulance and their structures were elucidated by spectroscopic techniques. The latter compound was found to be active against a number of potentially pathogenic fungi.

摘要

从凝乳茄全株中分离出两种新的睡茄内酯，即14,15β-环氧睡茄内酯I [（20S，22R）17β，20β-二羟基-14β，15β-环氧-1-氧代-威斯塔-3,5,24-三烯醇内酯]和17β-羟基睡茄内酯K [（20S，22R）14α，17β，20β-三羟基-1-氧代-威斯塔-2,5,24-三烯醇内酯]，并通过光谱技术阐明了它们的结构。发现后一种化合物对多种潜在致病真菌具有活性。