Saleem Sumaira, Muhammad Gulzar, Hussain Muhammad Ajaz, Altaf Muhammad, Bukhari Syed Nasir Abbas
Department of Chemistry, GC University Lahore, Lahore 54000 Pakistan.
Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan.
Iran J Basic Med Sci. 2020 Dec;23(12):1501-1526. doi: 10.22038/IJBMS.2020.44254.10378.
L. is a multipurpose medicinal plant of family occurring abundantly in sub-tropical regions of the world. The folk healers used the plant to treat several diseases such as fever, cancer, asthma, diabetes, ulcer, hepatitis, eyesores, arthritis, heart problems, and hemorrhoids. The plant is famous for the anti-cancerous activity, low back pain treatment, and muscle strengthening, which may be attributed to the withanolide alkaloids. is also rich in numerous valued secondary metabolites such as steroids, alkaloids, flavonoids, phenolics, saponins, and glycosides. A wide range of preclinical trials such as cardioprotective, anticancer, antioxidant, antibacterial, antifungal, anti-inflammatory, hepatoprotective, anti-depressant, and hypoglycemic have been attributed to various parts of the plant. Different parts of the plant have also been evaluated for the clinical trials such as male infertility, obsessive-compulsive disorder, antianxiety, bone and muscle strengthening potential, hypolipidemic, and antidiabetic. This review focuses on folk medicinal uses, phytochemistry, pharmacological, and nutrapharmaceutical potential of the versatile plant.
L.是一种多用途药用植物，在世界亚热带地区大量生长。民间治疗师用这种植物治疗多种疾病，如发烧、癌症、哮喘、糖尿病、溃疡、肝炎、眼疾、关节炎、心脏问题和痔疮。该植物以其抗癌活性、治疗腰痛和增强肌肉的作用而闻名，这可能归因于茄烷类生物碱。它还富含许多有价值的次生代谢产物，如甾体、生物碱、黄酮类、酚类、皂苷和糖苷。该植物的各个部位已被证明具有多种临床前试验作用，如心脏保护、抗癌、抗氧化、抗菌、抗真菌、抗炎、肝脏保护、抗抑郁和降血糖。该植物的不同部位也已针对男性不育、强迫症、抗焦虑、骨骼和肌肉增强潜力、降血脂和抗糖尿病等临床试验进行了评估。本综述重点关注这种多功能植物的民间药用用途、植物化学、药理学和营养药物潜力。
