Mori M, Yamada T, Doi T, Ohmura H, Takai Y, Shrestha P
Department of Oral and Maxillofacial Surgery, Asahi University School of Dentistry, Gifu, Japan.
Eur J Cancer B Oral Oncol. 1995 Jul;31B(4):275-9. doi: 10.1016/0964-1955(95)00002-y.
We investigated the expression of tenascin in a series of odontogenic tumours (n = 63) of epithelial and epithelial-ectomesenchymal origin by using immunohistochemical methods. A heterogeneity of expression of tenascin was observed in odontogenic tumours. The heterogeneity was most prominent in odontogenic tumours not forming calcified tissues. In these ameloblastomas and adenomatoid odontogenic tumours, tenascin was mainly localised at the epithelial tumour cell-mesenchymal tissue interface. In the calcifying epithelial odontogenic tumour, ameloblastic fibroma and odontoma, a widespread stromal immunoreactivity was observed which was, however, unreactive in the calcified masses. The stellate reticulum-like cells and granular cells of ameloblastoma also showed a positive immunoreactivity for tenascin. The results of the present study suggest that expression of tenascin in the stromal tissue of odontogenic tumours differs according to the potential of forming calcified masses by the tumour cells irrespective of tumour cell morphology.
我们采用免疫组织化学方法，研究了一系列上皮及上皮-外胚间充质来源的牙源性肿瘤（n = 63）中肌腱蛋白的表达情况。在牙源性肿瘤中观察到肌腱蛋白表达存在异质性。这种异质性在不形成钙化组织的牙源性肿瘤中最为显著。在这些成釉细胞瘤和腺样牙源性肿瘤中，肌腱蛋白主要定位于上皮肿瘤细胞与间充质组织的界面。在钙化上皮性牙源性肿瘤、成釉细胞纤维瘤和牙瘤中，观察到广泛的基质免疫反应性，然而，在钙化团块中无反应。成釉细胞瘤的星网状样细胞和颗粒细胞对肌腱蛋白也显示出阳性免疫反应性。本研究结果表明，牙源性肿瘤基质组织中肌腱蛋白的表达根据肿瘤细胞形成钙化团块的潜能而有所不同，与肿瘤细胞形态无关。
