Miller M A, Thibert L, Desjardins F, Siddiqi S H, Dascal A
McGill University, Montreal, Quebec, Canada.
J Clin Microbiol. 1995 Sep;33(9):2468-70. doi: 10.1128/jcm.33.9.2468-2470.1995.
The susceptibility of 428 clinical isolates of Mycobacterium tuberculosis to pyrazinamide was assessed by the Bactec method and the Wayne pyrazinamidase assay. The correlation between the two tests was 98.2 and 100% for susceptible and resistant strains, respectively. False resistance was seen in four (0.8%) strains with the Bactec test, and false-susceptible results occurred in two (0.5%) pyrazinamidase assays. The Bactec test is rapid and reliable, and the Bactec results correlate well with the pyrazinamidase test results, although some strains did not grow well in the test medium.
采用Bactec法和韦恩吡嗪酰胺酶测定法评估了428株结核分枝杆菌临床分离株对吡嗪酰胺的敏感性。对于敏感菌株和耐药菌株，两种检测方法的相关性分别为98.2%和100%。在Bactec检测中有4株（0.8%）菌株出现假耐药，在吡嗪酰胺酶测定中有2株（0.5%）出现假敏感结果。Bactec检测快速可靠，尽管有些菌株在测试培养基中生长不佳，但Bactec检测结果与吡嗪酰胺酶检测结果相关性良好。
