白细胞介素-12的体内抗病毒活性由γ干扰素介导。
The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon.
作者信息
Ozmen L, Aguet M, Trinchieri G, Garotta G
机构信息
Pharma Research Gene Technology, F. Hoffmann La-Roche Ltd., Basel, Switzerland.
出版信息
J Virol. 1995 Dec;69(12):8147-50. doi: 10.1128/JVI.69.12.8147-8150.1995.
Abstract
The injection of 20 ng of mouse interleukin-12 (IL-12) protects mice from a lethal infection with encephalomyocarditis virus. In vitro, an anti-gamma interferon (anti-IFN-gamma) monoclonal antibody but not an anti-IL-12 monoclonal antibody neutralizes the antiviral activity present in the supernatants of splenocytes stimulated with IL-12. Finally, IL-12 fails to protect 129 Sv/Ev IFN-gamma R0/0 mice against encephalomyocarditis virus infection. These results demonstrate that IL-12 exerts its antiviral activity through the induction of endogenous IFN-gamma.
摘要
注射20纳克小鼠白细胞介素-12（IL-12）可保护小鼠免受脑心肌炎病毒的致死性感染。在体外，抗γ干扰素（抗IFN-γ）单克隆抗体而非抗IL-12单克隆抗体可中和用IL-12刺激的脾细胞上清液中存在的抗病毒活性。最后，IL-12无法保护129 Sv/Ev IFN-γ R0/0小鼠免受脑心肌炎病毒感染。这些结果表明，IL-12通过诱导内源性IFN-γ发挥其抗病毒活性。
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