潜伏性水痘带状疱疹病毒DNA的构型
Configuration of latent varicella-zoster virus DNA.
作者信息
Clarke P, Beer T, Cohrs R, Gilden D H
机构信息
Department of Neurology, University of Colorado Health Sciences Center, Denver 80262, USA.
出版信息
J Virol. 1995 Dec;69(12):8151-4. doi: 10.1128/JVI.69.12.8151-8154.1995.
Abstract
The configuration of latent varicella-zoster virus (VZV) DNA was analyzed by PCR. Template DNA for both internal and terminal VZV primers was present in a 1:1 ratio in ganglionic DNA, compared with a 15:1 ratio in DNA extracted from VZV virions, indicating that the VZV genomic termini are adjacent in latently infected human ganglia.
摘要
通过聚合酶链反应（PCR）分析潜伏性水痘带状疱疹病毒（VZV）DNA的构型。与从VZV病毒粒子中提取的DNA中15:1的比例相比，神经节DNA中用于VZV内部和末端引物的模板DNA以1:1的比例存在，这表明VZV基因组末端在潜伏感染的人类神经节中是相邻的。
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