Levine M, Dhariwal K R, Welch R W, Wang Y, Park J B
Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0850, USA.
Am J Clin Nutr. 1995 Dec;62(6 Suppl):1347S-1356S. doi: 10.1093/ajcn/62.6.1347S.
Although the recommended dietary allowance provides an estimate for vitamin C ingestion in humans, optimal vitamin C requirements are unknown. We define optimal vitamin C requirements operationally based on the following: dose-function relations, availability in the food supply, steady state concentrations in plasma and tissues achieved at each dose of vitamin C, urinary excretion, bioavailability, toxicity, and epidemiologic observations. Optimal vitamin C requirements can be estimated when information is available for at least some of these criteria.
尽管推荐膳食摄入量提供了人类维生素C摄入量的估计值，但最佳维生素C需求量尚不清楚。我们基于以下因素从操作层面定义最佳维生素C需求量：剂量-功能关系、食物供应中的可获取性、每剂维生素C在血浆和组织中达到的稳态浓度、尿排泄、生物利用度、毒性以及流行病学观察结果。当至少有部分这些标准的相关信息可用时，就可以估算最佳维生素C需求量。
