Traber M G, Packer L
Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.
Am J Clin Nutr. 1995 Dec;62(6 Suppl):1501S-1509S. doi: 10.1093/ajcn/62.6.1501S.
Vitamin E, a potent peroxyl radical scavenger, is a chain-breaking antioxidant that prevents the propagation of free radical damage in biological membranes. We consider the evidence for potential sites in cellular metabolism and signal transduction where vitamin E may have a structure-specific role in addition to its antioxidant function. The roles of tocopherol-binding proteins in cellular trafficking of vitamin E, especially the incorporation of RRR-alpha-tocopherol into nascent lipoproteins, and the delivery of RRR-alpha-tocopherol to the nucleus are considered. We discuss the functions of vitamin E both in the inhibition and potentiation of arachidonic acid metabolism. The interactions of vitamin E during cell proliferation and differentiation are also evaluated. These functions of vitamin E raise new questions and represent new and exciting areas for research in cell regulation with physiologic implications.
维生素E是一种强效的过氧自由基清除剂，是一种断链抗氧化剂，可防止生物膜中自由基损伤的传播。我们研究了细胞代谢和信号转导中潜在位点的证据，除了其抗氧化功能外，维生素E在这些位点可能具有结构特异性作用。我们考虑了生育酚结合蛋白在维生素E细胞转运中的作用，特别是RRR-α-生育酚掺入新生脂蛋白以及RRR-α-生育酚向细胞核的递送。我们讨论了维生素E在抑制和增强花生四烯酸代谢中的作用。还评估了维生素E在细胞增殖和分化过程中的相互作用。维生素E的这些功能提出了新问题，并代表了细胞调节研究中具有生理意义的新的令人兴奋的领域。
