Pathak Neelam, Singh Pankaj, Singh Pradeep Kumar, Sharma Swati, Singh Rajat Pratap, Gupta Anmol, Mishra Richa, Mishra Vivek Kumar, Tripathi Manikant
Department of Biochemistry, Dr. Rammanohar Lohia Avadh University, Ayodhya, India.
Biotechnology Programme, Dr. Rammanohar Lohia Avadh University, Ayodhya, India.
Front Nutr. 2022 Jul 15;9:963413. doi: 10.3389/fnut.2022.963413. eCollection 2022.
Nowadays, effective cancer therapy is a global concern, and recent advances in nanomedicine are crucial. Cancer is one of the major fatal diseases and a leading cause of death globally. Nanotechnology provides rapidly evolving delivery systems in science for treating diseases in a site-specific manner using natural bioactive compounds, which are gaining widespread attention. Nanotechnology combined with bioactives is a very appealing and relatively new area in cancer treatment. Natural bioactive compounds have the potential to be employed as a chemotherapeutic agent in the treatment of cancer, in addition to their nutritional benefits. Alginate, pullulan, cellulose, polylactic acid, chitosan, and other biopolymers have been effectively used in the delivery of therapeutics to a specific site. Because of their biodegradability, biopolymeric nanoparticles (BNPs) have received a lot of attention in the development of new anticancer drug delivery systems. Biopolymer-based nanoparticle systems can be made in a variety of ways. These systems have developed as a cost-effective and environmentally friendly solution to boost treatment efficacy. Effective drug delivery systems with improved availability, increased selectivity, and lower toxicity are needed. Recent research findings and current knowledge on the use of BNPs in the administration of bioactive chemicals in cancer therapy are summarized in this review.
如今,有效的癌症治疗是全球关注的问题,纳米医学的最新进展至关重要。癌症是主要的致命疾病之一,也是全球主要的死亡原因。纳米技术在科学领域提供了快速发展的递送系统,用于使用天然生物活性化合物以位点特异性方式治疗疾病,这正受到广泛关注。纳米技术与生物活性物质相结合是癌症治疗中一个非常有吸引力且相对较新的领域。天然生物活性化合物除了具有营养益处外,还具有作为癌症治疗化疗药物的潜力。海藻酸盐、普鲁兰多糖、纤维素、聚乳酸、壳聚糖和其他生物聚合物已有效地用于将治疗剂递送至特定部位。由于其生物可降解性,生物聚合物纳米颗粒(BNP)在新型抗癌药物递送系统的开发中受到了广泛关注。基于生物聚合物的纳米颗粒系统可以通过多种方式制备。这些系统已发展成为一种经济高效且环境友好的解决方案,以提高治疗效果。需要具有更高可用性、更高选择性和更低毒性的有效药物递送系统。本综述总结了近期关于在癌症治疗中使用BNP给药生物活性化学物质的研究发现和当前知识。