臭椿的成分及细胞毒性原理。

Constituents and cytotoxic principles of Nothapodytes foetida.

作者信息

Wu T S, Leu Y L, Hsu H C, Ou L F, Chen C C, Chen C F, Ou J C, Wu Y C

机构信息

Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, R.O.C.

出版信息

Phytochemistry. 1995 May;39(2):383-5. doi: 10.1016/0031-9422(94)00901-5.

DOI:10.1016/0031-9422(94)00901-5

PMID:7495532

Abstract

A new naturally occurring alkaloid, acetylcamptothecin, together with 17 known compounds, (+)-1-hydroxypinoresinol, omega-hydroxypropioguaiacone, p-hydroxybenzaldehyde, scopoletin, uracil, thymine, sitosterol, sitosteryl-beta-D-glucoside, 3 beta-hydroxy-stigmast-5-en-7-one, stigmast-5-en-3 beta,7 alpha-diol, 6 beta-hydroxystigmast-4-en-3-one, sitost-4-en-3-one, linoleic acid, trigonelline, camptothecin, 9-O-methoxycamptothecin and pumiloside were isolated and characterized from the stem of Nothapodytes foetida. Among them, scopoletin, camptothecin, 9-O-methoxycamptothecin and O-acetylcamptothecin showed significant cytotoxic activity.

摘要

从臭假柴龙树茎中分离并鉴定出一种新的天然生物碱乙酰喜树碱，以及17种已知化合物，即(+)-1-羟基松脂醇、ω-羟基苯并呋喃酮、对羟基苯甲醛、东莨菪素、尿嘧啶、胸腺嘧啶、谷甾醇、谷甾醇-β-D-葡萄糖苷、3β-羟基-豆甾-5-烯-7-酮、豆甾-5-烯-3β,7α-二醇、6β-羟基豆甾-4-烯-3-酮、豆甾-4-烯-3-酮、亚油酸、胡芦巴碱、喜树碱、9-O-甲氧基喜树碱和矮牵牛苷。其中，东莨菪素、喜树碱、9-O-甲氧基喜树碱和O-乙酰喜树碱表现出显著的细胞毒活性。