Gunasekera S P, Badawi M M, Cordell G A, Farnsworth N R, Chitnis M
J Nat Prod. 1979 Sep-Oct;42(5):475-7. doi: 10.1021/np50005a006.
The anticancer activity of the roots of Ervatamia heyneana (Apocynaceae) was found to be due principally to the known alkaloid, camptothecin (1). The closely related, but less active, 9-methoxycamptothecin (2) was also obtained. This is the first reported isolation of these biogenetically interesting alkaloids from the indole alkaloid rich Apocynaceae.
人们发现，狗牙花（夹竹桃科）根的抗癌活性主要归因于已知生物碱喜树碱（1）。还得到了与之密切相关但活性较低的9-甲氧基喜树碱（2）。这是首次报道从富含吲哚生物碱的夹竹桃科植物中分离出这些具有生物合成意义的生物碱。
