经食管超声心动图随访观察抗凝治疗下左心房血栓的演变
Evolution of left atrial thrombus with anticoagulant therapy-follow-up by transesophageal echocardiography.
作者信息
Kim C H, Park S W, Zo J H, Oh B H, Lee M M, Seo J D, Lee Y W
机构信息
Department of Internal Medicine, Seoul National University College of Medicine, Korea.
出版信息
Korean J Intern Med. 1995 Jul;10(2):143-5. doi: 10.3904/kjim.1995.10.2.143.
OBJECTIVES
Atrial fibrillation is an important risk factor for systemic embolism. A number of clinical studies demonstrated the beneficial effect of anticoagulant therapy for the prevention of embolism. But there has been no study on the fate of left atrial thrombus demonstrated by transesophageal echocardiography in the course of anticoagulation therapy.
METHODS
Thirteen patients, demonstrated to have left atrial thrombus by transesophageal echocardiography were followed with anticoagulation therapy. Repeated transesophageal echocardiography was done 15 months after 1st study.
RESULTS
Among 9 patients with adequate anticoagulation effect (INR > 2.0), left atrial thrombus disappeared in 3 patients. The size of thrombus decreased from 2.2 +/- 0.8cm to 0.9 +/- 1.0cm (p < 0.05 by paired Student's t-test).
CONCLUSIONS
Left atrial thrombus could dissolve or decrease in size with adequate anticoagulation.
目的
心房颤动是全身性栓塞的重要危险因素。多项临床研究证明了抗凝治疗对预防栓塞的有益作用。但对于经食管超声心动图显示的左心房血栓在抗凝治疗过程中的转归尚无研究。
方法
对13例经食管超声心动图显示有左心房血栓的患者进行抗凝治疗随访。在首次检查后15个月进行重复经食管超声心动图检查。
结果
在抗凝效果良好（国际标准化比值>2.0）的9例患者中，3例左心房血栓消失。血栓大小从2.2±0.8cm减小至0.9±1.0cm（配对t检验，p<0.05）。
结论
充分抗凝可使左心房血栓溶解或缩小。
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