Eijsbouts A M, Witteman B J, de Sévaux R G, Fennis J F, van Haelst U J, Naber A H, Jansen J B
Department of Gastroenterology and Hepatology, Nijmegen University Hospital, The Netherlands.
Eur J Gastroenterol Hepatol. 1995 Aug;7(8):803-6.
A 47-year-old man with a flat jejunal mucosa complicated by malabsorption, diarrhoea and lymphocytic colitis is presented. There was no response to gluten withdrawal alone, combination of a gluten-free diet and prednisone therapy, or total parenteral nutrition. Complete clinical remission was only achieved after simultaneous treatment with cyclosporine and a gluten-free diet. Rechallenge with a gluten-containing diet while cyclosporine treatment continued resulted in a relapse of diarrhoea and malabsorption. We conclude that cyclosporine may be an effective agent for the treatment of undefined, refractory forms of malabsorption.
