Chao C C, Hu S, Frey W H, Ala T A, Tourtellotte W W, Peterson P K
Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, MN 55404, USA.
Clin Diagn Lab Immunol. 1994 Jan;1(1):109-10. doi: 10.1128/cdli.1.1.109-110.1994.
Alzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD patients < 6 h after death. Serum TGF-beta levels were also markedly elevated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically mediated neuronal injury.
阿尔茨海默病（AD）被认为是一种炎症性疾病。我们推测抗炎细胞因子，如转化生长因子β（TGF-β），可对抗炎症过程。在本研究中，我们发现从AD患者死后6小时内获得的脑脊液和血清样本中，TGF-β水平均升高。血清TGF-β水平在死亡前也显著升高。这些结果表明，AD中TGF-β水平升高可能代表宿主对免疫介导的神经元损伤的一种保护性反应。
