Peterson P K, Sirr S A, Grammith F C, Schenck C H, Pheley A M, Hu S, Chao C C
Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 54415, USA.
Clin Diagn Lab Immunol. 1994 Mar;1(2):222-6. doi: 10.1128/cdli.1.2.222-226.1994.
Chronic fatigue syndrome (CFS) is an idiopathic disorder characterized by fatigue that is markedly exacerbated by physical exertion. In the present study, we tested the hypothesis that mild exercise (walking 1 mph [1 mile = 1.609 km] for 30 min) would provoke serum cytokine and cerebral blood flow abnormalities of potential pathogenic importance in CFS. Interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha were nondetectable in sera of CFS patients (n = 10) and healthy control subjects (n = 10) pre- and postexercise. At rest, serum transforming growth factor beta (TGF-beta) levels were elevated in the CFS group compared with the control group (287 +/- 18 versus 115 +/- 5 pg/ml, respectively; P < 0.01). Serum TGF-beta and cerebral blood flow abnormalities, detected by single-photon emission-computed tomographic scanning, were accentuated postexercise in the CFS group. Although these findings were not significantly different from those in the control group, the effect of exercise on serum TGF-beta and cerebral blood flow appeared magnified in the CFS patients. Results of this study encourage future research on the interaction of physical exertion, serum cytokines, and cerebral blood flow in CFS that will adopt a more rigorous exercise program than the one used in this study.
慢性疲劳综合征（CFS）是一种特发性疾病，其特征为疲劳，且体力活动会使其显著加重。在本研究中，我们检验了这样一个假设：轻度运动（以每小时1英里[1英里 = 1.609千米]的速度步行30分钟）会引发慢性疲劳综合征中具有潜在致病重要性的血清细胞因子和脑血流量异常。在运动前和运动后，慢性疲劳综合征患者（n = 10）和健康对照者（n = 10）的血清中均未检测到白细胞介素-1β、白细胞介素-6和肿瘤坏死因子α。静息时，慢性疲劳综合征组的血清转化生长因子β（TGF-β）水平高于对照组（分别为287 ± 18与115 ± 5 pg/ml；P < 0.01）。通过单光子发射计算机断层扫描检测到，慢性疲劳综合征组运动后血清TGF-β和脑血流量异常加剧。尽管这些结果与对照组的结果无显著差异，但运动对血清TGF-β和脑血流量的影响在慢性疲劳综合征患者中似乎更为明显。本研究结果鼓励未来开展关于慢性疲劳综合征中体力活动、血清细胞因子和脑血流量相互作用的研究，该研究将采用比本研究中使用的更为严格的运动方案。
